Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa

Sachiko Tsukamoto; Kyoko Tomise; Maki Aburatani; Hiroyuki Onuki; Hiroshi Hirorta; Eiji Ishiharajima; Tomihisa Ohta

doi:10.1021/np0400104

Isolation of cytochrome P450 inhibitors from strawberry fruit, Fragaria ananassa

J Nat Prod. 2004 Nov;67(11):1839-41. doi: 10.1021/np0400104.

Authors

Sachiko Tsukamoto¹, Kyoko Tomise, Maki Aburatani, Hiroyuki Onuki, Hiroshi Hirorta, Eiji Ishiharajima, Tomihisa Ohta

Affiliation

¹ Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920-0934, Japan.

PMID: 15568772
DOI: 10.1021/np0400104

Abstract

A new glycoside, 2-beta-d-glucopyranosyloxy-4,6-dihydroxyisovalerophenone (3), was isolated from strawberry fruit along with kaempferol-3-beta-D-(6-O-trans-p-coumaroyl)glucopyranoside (1) and kaempferol-3-beta-D-(6-O-cis-p-coumaroyl)glucopyranoside (2). Compounds 1 and 2 inhibited activity of a drug-metabolizing enzyme, CYP3A4.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Fragaria / chemistry*
Fruit / chemistry
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology
Kaempferols / chemistry
Kaempferols / isolation & purification*
Kaempferols / pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plants, Medicinal / chemistry*

Substances

2-beta-D-glucopyranosyloxy-4,6-dihydroxyisovalerophenone
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors
Glycosides
Kaempferols
kaempferol-3-beta-D-(6-O-trans-p-coumaroyl)glucopyranoside
CYP3A protein, human
Cytochrome P-450 CYP3A
CYP3A4 protein, human